Yuki N, Kubo M, Noro Y, Hayashi N, Fusamoto H, Ito A, Masuzawa M, Kamada T
Dept. of Internal Medicine, Osaka Police Hospital, Japan.
Scand J Gastroenterol. 1991 Oct;26(10):1075-81. doi: 10.3109/00365529109003959.
Urinary kinin and urinary kallikrein activity were measured in 33 liver cirrhotics, and the values were correlated with the severity of the liver disease. A significant relationship was observed between urinary kinin excretion and urinary kallikrein excretion (r = 0.53; p less than 0.01). Both urinary kinin and kallikrein excretion were significantly lower in Child's group C than in Child's groups A and B (p less than 0.05) and showed positive correlations with serum albumin (r = 0.47, p less than 0.01 and r = 0.46, p less than 0.01, respectively). Increases in urinary kinin and kallikrein excretion after endoscopic variceal sclerotherapy were observed in 18 patients (p less than 0.01 and p less than 0.05, respectively). These results suggest that the renal kallikrein-kinin system in suppressed in severe liver disease in proportion to the severity of the underlying liver disease. In this study possible activation of this system after sclerotherapy was also demonstrated.
对33例肝硬化患者测定了尿激肽和尿激肽释放酶活性，并将这些值与肝病的严重程度进行关联分析。观察到尿激肽排泄与尿激肽释放酶排泄之间存在显著相关性（r = 0.53；p < 0.01）。Child C组的尿激肽和激肽释放酶排泄均显著低于Child A组和B组（p < 0.05），且与血清白蛋白呈正相关（分别为r = 0.47，p < 0.01和r = 0.46，p < 0.01）。18例患者在内镜下硬化剂治疗后尿激肽和激肽释放酶排泄增加（分别为p < 0.01和p < 0.05）。这些结果表明，严重肝病时肾激肽释放酶 - 激肽系统受到抑制，且与潜在肝病的严重程度成比例。本研究还证实了硬化剂治疗后该系统可能被激活。
