在一个斯堪的纳维亚病例对照样本中，DGKH与双相情感障碍之间无关联。
No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
作者信息
Tesli Martin, Kähler Anna K, Andreassen Bettina Kulle, Werge Thomas, Mors Ole, Mellerup Erling, Koefoed Pernille, Melle Ingrid, Morken Gunnar, Wirgenes Katrine V, Andreassen Ole A, Djurovic Srdjan
机构信息
Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway.
出版信息
Psychiatr Genet. 2009 Oct;19(5):269-72. doi: 10.1097/YPG.0b013e32832d302f.
Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
二酰基甘油激酶η（DGKH）中的单核苷酸多态性（SNP）最近已被证明与双相情感障碍（BD）有关。为了重复这一发现，我们对DGKH中的36个标签SNP进行了全基因分型，并在两个斯堪的纳维亚样本上进行了基于人群的关联研究，成功对594例BD病例和1421名健康对照进行了基因分型。在我们的样本中，经过多重检验校正后，我们发现这些SNP中的任何一个与BD之间均无显著关联。因此，在这个庞大的斯堪的纳维亚样本中，这些基因变异不太可能导致BD易感性。
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