Henson Sian M, Akbar Arne N
Division of Infection and Immunity, Department of Immunology, University College London, 46 Cleveland Street, London, UK.
Age (Dordr). 2009 Dec;31(4):285-91. doi: 10.1007/s11357-009-9100-9.
The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role. In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling.
共抑制受体杀伤细胞凝集素样受体G1（KLRG1）在自然杀伤（NK）细胞和经历过抗原刺激的T细胞上表达，并且被认为是衰老的标志物。虽然KLRG1经常被用作细胞分化的标志物，但越来越多的数据表明KLRG1发挥抑制作用。在这篇综述中，我们研究了突出KLRG1这一观点的证据，重点关注随着年龄增长在T细胞分化过程中出现的功能缺陷，这些缺陷可能部分由抑制性受体信号传导主动维持。
