Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
J Neurosurg. 2010 Jan;112(1):130-2. doi: 10.3171/2009.5.JNS08442.
Peritumoral hemangioblastoma cysts are usually composed of fibrous tissue without tumor cells. The authors describe the first case in which fluorescence with 5-aminolevulinic acid (5-ALA) was used to diagnose a hemangioblastoma tumor in a peritumoral cyst wall. A 27-year-old woman with a homogeneous, enhanced nodular lesion in the right hemisphere of the cerebellum underwent surgical treatment. After the nodular lesion was removed, the cyst region was observed with the aid of a semiconductor laser with a peak wavelength of 405 +/- 1 nm, which was powered using a fiberoptic cable. The cyst region was visualized with strong fluorescence, which disappeared after tissue removal. The fluorescent cyst consisted of tumor cells. The authors conclude that fluorescence diagnosis performed using 5-ALA can inform the choice of removing hemangioblastoma cysts.
瘤周血管母细胞瘤囊肿通常由无肿瘤细胞的纤维组织构成。作者描述了首例应用 5-氨基乙酰丙酸（5-ALA）荧光诊断瘤周囊壁血管母细胞瘤的病例。一位 27 岁女性，右侧小脑半球有一均质强化结节状病变，接受了手术治疗。结节状病变切除后，在峰值波长为 405 +/- 1nm 的半导体激光的辅助下观察囊腔区域，激光能量由光纤电缆提供。囊腔区域呈现强荧光，组织切除后荧光消失。荧光的囊腔包含肿瘤细胞。作者得出结论，5-ALA 荧光诊断有助于选择切除血管母细胞瘤囊肿。
