Receptor-induced conformation change of the immunosuppressant cyclosporin A.

Suppr

超能文献

作者信息

Wüthrich K, von Freyberg B, Weber C, Wider G, Traber R, Widmer H, Braun W

机构信息

Institut für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule-Hönggerberg, Zürich, Switzerland.

出版信息

Science. 1991 Nov 15;254(5034):953-4. doi: 10.1126/science.1948082.

DOI:10.1126/science.1948082

PMID:1948082

Abstract

摘要

相似文献

Receptor-induced conformation change of the immunosuppressant cyclosporin A.

Science. 1991 Nov 15;254(5034):953-4. doi: 10.1126/science.1948082.

NMR studies of [U-13C]cyclosporin A bound to human cyclophilin B.与人类亲环蛋白B结合的[U-13C]环孢菌素A的核磁共振研究。

FEBS Lett. 1991 Sep 23;290(1-2):195-9. doi: 10.1016/0014-5793(91)81258-a.

Rusting of the lock and key model for protein-ligand binding.蛋白质-配体结合的锁钥模型的过时。

Science. 1991 Nov 15;254(5034):954-5. doi: 10.1126/science.1719636.

The 3D structure of a cyclosporin analogue in water is nearly identical to the cyclophilin-bound cyclosporin conformation.环孢菌素类似物在水中的三维结构与亲环蛋白结合的环孢菌素构象几乎相同。

FEBS Lett. 1994 Mar 7;340(3):255-9. doi: 10.1016/0014-5793(94)80149-5.

Interaction of cyclosporin A and two cyclosporin analogs with cyclophilin: relationship between structure and binding.环孢素A及两种环孢素类似物与亲环蛋白的相互作用：结构与结合之间的关系

J Chromatogr B Biomed Appl. 1994 Dec 9;662(2):301-6. doi: 10.1016/0378-4347(94)00211-8.

Solution structure of the cyclosporin A/cyclophilin complex by NMR.通过核磁共振确定的环孢菌素A/亲环蛋白复合物的溶液结构

Nature. 1993 Jan 7;361(6407):88-91. doi: 10.1038/361088a0.

Molecular modeling studies in the complex between cyclophilin and cyclosporin A.

Protein Eng. 1992 Jul;5(5):391-7. doi: 10.1093/protein/5.5.391.

Preliminary analysis of multiple crystal forms of the bovine cyclophilin-cyclosporin A complex.

J Mol Biol. 1994 Jan 21;235(3):1136-40. doi: 10.1006/jmbi.1994.1062.

Conformational polymorphism of cyclosporin A.环孢菌素A的构象多态性

Structure. 1994 Oct 15;2(10):963-72. doi: 10.1016/s0969-2126(94)00098-0.

A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex.环孢菌素A- Fab复合物的X射线结构揭示的环孢菌素A在水环境中的构象。

Science. 1992 Apr 3;256(5053):92-4. doi: 10.1126/science.1566062.

引用本文的文献

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?亲环素 D 在线粒体功能障碍中的作用：神经退行性变的关键因素？

Biomolecules. 2023 Aug 18;13(8):1265. doi: 10.3390/biom13081265.

Molecular aspects of cyclophilins mediating therapeutic actions of their ligands.环孢素结合蛋白介导其配体治疗作用的分子方面。

Cell Mol Life Sci. 2010 Oct;67(20):3467-88. doi: 10.1007/s00018-010-0437-0. Epub 2010 Jul 4.

1H and 13C-NMR and molecular dynamics studies of cyclosporin a interacting with magnesium(II) or cerium(III) in acetonitrile. Conformational changes and cis-trans conversion of peptide bonds.环孢菌素A在乙腈中与镁（II）或铈（III）相互作用的1H和13C核磁共振及分子动力学研究。肽键的构象变化和顺反异构化。

Biophys J. 2006 Feb 15;90(4):1350-61. doi: 10.1529/biophysj.105.074245. Epub 2005 Nov 18.

A review of protein-small molecule docking methods.蛋白质-小分子对接方法综述。

J Comput Aided Mol Des. 2002 Mar;16(3):151-66. doi: 10.1023/a:1020155510718.

The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811.人类免疫缺陷病毒1型衣壳p2结构域赋予对亲环素结合药物SDZ NIM 811的敏感性。

J Virol. 1996 Sep;70(9):5751-7. doi: 10.1128/JVI.70.9.5751-5757.1996.

Modeling conformational changes in cyclosporin A.环孢菌素A构象变化的建模

Protein Sci. 1995 Oct;4(10):2191-202. doi: 10.1002/pro.5560041025.

Analysis of cyclic and acyclic nicotinic cholinergic agonists using radioligand binding, single channel recording, and nuclear magnetic resonance spectroscopy.使用放射性配体结合、单通道记录和核磁共振光谱法对环状和非环状烟碱型胆碱能激动剂进行分析。

Biophys J. 1993 Feb;64(2):325-38. doi: 10.1016/S0006-3495(93)81373-0.

Determination of the NMR solution structure of the cyclophilin A-cyclosporin A complex.亲环蛋白A-环孢菌素A复合物的核磁共振溶液结构测定

J Biomol NMR. 1994 Jul;4(4):463-82. doi: 10.1007/BF00156614.

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.环孢素。对其药效学和药代动力学特性以及在免疫调节紊乱中的治疗应用的综述。

Drugs. 1993 Jun;45(6):953-1040. doi: 10.2165/00003495-199345060-00007.

Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.亲环素与人免疫缺陷病毒1型Gag多蛋白的结合可被一种抗环孢素抗体模拟。

J Virol. 1995 Sep;69(9):5821-3. doi: 10.1128/JVI.69.9.5821-5823.1995.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验