精神分裂症与AP-3复合体基因之间的关联分析
Association analysis between schizophrenia and the AP-3 complex genes.
作者信息
Hashimoto Ryota, Ohi Kazutaka, Okada Takeya, Yasuda Yuka, Yamamori Hidenaga, Hori Hiroaki, Hikita Takao, Taya Shinichiro, Saitoh Osamu, Kosuga Asako, Tatsumi Masahiko, Kamijima Kunitoshi, Kaibuchi Kozo, Takeda Masatoshi, Kunugi Hiroshi
机构信息
The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
出版信息
Neurosci Res. 2009 Sep;65(1):113-5. doi: 10.1016/j.neures.2009.05.008. Epub 2009 May 27.
A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia (chi(2)=6.33, P=0.012, odds ratio=0.80) was no longer positive after correction for multiple testing (corrected P=0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
精神分裂症的一个易感基因——发动蛋白，是BLOC-1的一个组成部分，BLOC-1与衔接蛋白（AP）-3复合物相互作用。由于有报道称发动蛋白与AP-3复合物之间存在直接相互作用，我们使用432例患者和656名对照，研究了AP3复合物基因中的16个单核苷酸多态性（SNP）与精神分裂症之间可能存在的关联。AP3M1基因中的rs6688与精神分裂症之间的名义关联（卡方=6.33，P=0.012，优势比=0.80）在经过多重检验校正后不再显著（校正后P=0.192）。目前的结果表明，在该人群中，AP3复合物基因可能在精神分裂症的发病机制中不发挥主要作用。
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