扁枝衣酸和一种来自日本树发的新型苯并呋喃——佐木树发素A的抗有丝分裂活性。
Antimitotic activity of lobaric acid and a new benzofuran, sakisacaulon A from Stereocaulon sasakii.
作者信息
Morita Hiroshi, Tsuchiya Tomoe, Kishibe Koji, Noya Sayaka, Shiro Motoo, Hirasawa Yusuke
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
出版信息
Bioorg Med Chem Lett. 2009 Jul 1;19(13):3679-81. doi: 10.1016/j.bmcl.2009.03.170. Epub 2009 May 12.
PMID:19481447
Abstract
Lobaric acid (1) has been isolated from lichen, Stereocaulon sasakii together with a new benzofuran, sakisacaulon A (2). Lobaric acid (1) inhibited the polymerization of tubulin. Structure-activity relationship of lobaric acid and its derivatives on inhibitory activity of tubulin polymerization was discussed.
摘要
从地衣类植物萨氏石蕊（Stereocaulon sasakii）中分离得到了洛巴酸（1）以及一种新的苯并呋喃类化合物——萨氏石蕊A（2）。洛巴酸（1）可抑制微管蛋白的聚合。文中讨论了洛巴酸及其衍生物对微管蛋白聚合抑制活性的构效关系。
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