Krebs Arnaud, Tora László
Functional Genomics Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, ILLKIRCH, France.
Mol Cell. 2009 May 14;34(4):397-9. doi: 10.1016/j.molcel.2009.05.004.
In this issue of Molecular Cell, Takahata et al. (2009) dissect the mechanisms preceding transcription initiation, revealing a wave of nucleosome eviction, which spreads from distant cis-regulatory elements to promoters and which requires the activity of histone chaperones, FACT and Asf1.
在本期《分子细胞》杂志中,高畑等人(2009年)剖析了转录起始之前的机制,揭示了一波核小体驱逐现象,该现象从远处的顺式调控元件扩散至启动子,且需要组蛋白伴侣FACT和Asf1的活性。