孕中期循环中的松弛素和宫颈长度与自发性早产独立相关。

Circulating relaxin and cervical length in midpregnancy are independently associated with spontaneous preterm birth.

作者信息

Sandager Puk, Uldbjerg Niels, Henriksen Tine Brink, Goldsmith Laura T, Thorsen Poul, Weiss Gerson, Vogel Ida

机构信息

Y Research Laboratory, Department of Gynecology and Obstetrics, Aarhus University Hospital, Skejby, DK-8200 Aarhus N. Denmark.

出版信息

Am J Obstet Gynecol. 2009 Aug;201(2):169.e1-6. doi: 10.1016/j.ajog.2009.03.030. Epub 2009 May 30.

DOI:10.1016/j.ajog.2009.03.030

PMID:19481729

Abstract

OBJECTIVE

We sought to examine associations among serum relaxin levels, cervical length, and spontaneous preterm birth (sPTB).

STUDY DESIGN

We conducted a case-control study within a cohort of 1080 singleton pregnant women. In all, 38 women (3.5%) delivered spontaneously preterm (< 37 completed weeks of gestation). Relaxin was measured in serum in gestational weeks 12 and 19, cervical length only in week 19. Associations to sPTB were evaluated by logistic regression analysis and receiver operating characteristic curves.

RESULTS

Cervical length and relaxin in week 19, but not week 12 were associated to sPTB. There were no correlations between cervical length and relaxin level in week 12 (controls: Spearman rho: -0.07, P = .45; cases: Spearman rho: -0.07, P = .72) or week 19 (controls: Spearman rho: -0.03, P = .77; cases: Spearman rho: 0.04, P = .84).

CONCLUSION

There were no correlation between relaxin concentrations and the cervical length, indicating that relaxin is probably not the cause of preterm shortening of the cervix.

摘要

目的

我们试图研究血清松弛素水平、宫颈长度与自发性早产（sPTB）之间的关联。

研究设计

我们在1080名单胎孕妇队列中进行了一项病例对照研究。共有38名女性（3.5%）发生自发性早产（妊娠<37足周）。在妊娠第12周和第19周测定血清中的松弛素，仅在第19周测量宫颈长度。通过逻辑回归分析和受试者工作特征曲线评估与sPTB的关联。

结果

第19周而非第12周的宫颈长度和松弛素与sPTB相关。第12周（对照组：Spearman相关系数：-0.07，P = 0.45；病例组：Spearman相关系数：-0.07，P = 0.72）或第19周（对照组：Spearman相关系数：-0.03，P = 0.77；病例组：Spearman相关系数：0.04，P = 0.84）时，宫颈长度与松弛素水平之间均无相关性。