Vogel Ida, Goepfert Alice R, Møller Holger J, Cliver Suzanne, Thorsen Poul, Andrews William W
North Atlantic Neuro-epidemiology Alliances (NANEA), Department of Epidemiology, Institute for Public Health, University of Aarhus, Denmark.
Am J Obstet Gynecol. 2006 Jul;195(1):208-14. doi: 10.1016/j.ajog.2005.12.009. Epub 2006 Apr 5.
The purpose of this study was to evaluate the relationship between serum concentrations of relaxin and soluble CD163 with cervical length and preterm delivery in women with previous spontaneous preterm delivery.
Sixty-one of 69 pregnant women with a previous spontaneous preterm had serum relaxin and soluble CD163 measured at week 16 (range, 12-25 weeks). End points were cervical length and gestational age at delivery.
Of the 61 women, 26% had >1 previous spontaneous preterm delivery; 84% were black; 87% were unmarried; 13% were smokers, and 39% were delivered before 37 weeks of gestation. Neither relaxin (median, 368 ng/L; range, 83-1493 ng/L) nor soluble CD163 (2.4 mg/L; range, 0.86-6.85 mg/L) correlated with cervical length or gestational age at delivery. Black women had higher relaxin levels (436 vs 205 ng/L; P = .002), but soluble CD163 levels were similar among racial groups.
Relaxin and soluble CD163 measured at 16 weeks of gestation are not clinically useful predictors of short cervical length or preterm delivery in women with a previous spontaneous preterm delivery.
本研究旨在评估血清松弛素和可溶性CD163浓度与既往有自发性早产史的女性宫颈长度及早产之间的关系。
69例既往有自发性早产史的孕妇中有61例在孕16周（范围为12 - 25周）时检测了血清松弛素和可溶性CD163。终点指标为宫颈长度和分娩时的孕周。
61例女性中，26%有1次以上既往自发性早产史；84%为黑人；87%未婚；13%吸烟，39%在孕37周前分娩。松弛素（中位数为368 ng/L；范围为83 - 1493 ng/L）和可溶性CD163（2.4 mg/L；范围为0.86 - 6.85 mg/L）均与宫颈长度或分娩时的孕周无关。黑人女性的松弛素水平较高（436 ng/L对205 ng/L；P = 0.002），但种族之间可溶性CD163水平相似。
孕16周时检测的松弛素和可溶性CD163对既往有自发性早产史的女性宫颈长度缩短或早产并无临床预测价值。
