[The clinico-diagnostic significance of determining creatine kinase activity and isoenzymes in patients with systemic lupus erythematosus].

Creatine kinase (CK) activity was assessed in the direct and reverse tests and CK isoenzymes in agar gel for 41 patients with systemic lupus erythematosus (SLE). With growing activity of the process, there was a decline of CK activity in the reverse test though in the direct test this activity was scarcely changeable allowing a shift to predominance of the direct response. Significant differences were found in CK reverse reaction which correlated with SLE activity and pattern. The more active the disease, the less content of CK-1 and CK-3 isoenzymes. Investigations of CK activity and isoenzymes during SLE treatment help objectivize the clinical control.