Lee Eun Joo, In Kwang Ho, Ha Eun Sil, Lee Kyung Ju, Hur Gyu Young, Kang Eun Hae, Jung Ki Hwan, Lee Sung Yong, Kim Je Hyeong, Lee Sang Yeub, Shin Chol, Shim Jae Jeong, Kang Kyung Ho, Yoo Se Hwa
Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
J Asthma. 2009 May;46(4):339-42. doi: 10.1080/02770900802660931.
The prevalence of obesity and asthma has been increasing during the last several decades. Obesity has been reported to be associated with asthma. Obesity, especially abdominal obesity, is the main component of the metabolic syndrome.
We thus hypothesized that metabolic syndrome is an important contributing factor for the development of asthma-like symptoms.
The Korean Health and Genome Study started in 2001 as an ongoing population-based study of Korean adults 40 to 69 years of age. The prevalence of asthma-like symptoms in the previous 12 months was obtained by a questionnaire, and spirometric testing was conducted.
Among the 10,038 participants, the data from 9,942 individuals (4,716 men and 5,226 women) was available. Asthma-like symptoms (wheeze [p = 0.0006], resting dyspnea [p = 0.0062], and post-exercise dyspnea [p < 0.0001]) were increased in the subjects of the metabolic syndrome group. Subjects with asthma-like symptoms had a decreased lung function compared to subjects without asthma-like symptoms. Among the components of the metabolic syndrome, abdominal obesity and hypertension were the risk factors for asthma-like symptoms.
Metabolic syndrome is associated with asthma-like symptoms. Among the components of metabolic syndrome, abdominal obesity and hypertension are the risk factors for asthma-like symptoms.
在过去几十年中，肥胖症和哮喘的患病率一直在上升。据报道，肥胖与哮喘有关。肥胖，尤其是腹部肥胖，是代谢综合征的主要组成部分。
因此，我们假设代谢综合征是哮喘样症状发展的一个重要促成因素。
韩国健康与基因组研究始于2001年，是一项针对40至69岁韩国成年人的正在进行的基于人群的研究。通过问卷调查获取过去12个月内哮喘样症状的患病率，并进行肺功能测试。
在10,038名参与者中，有9,942人（4,716名男性和5,226名女性）的数据可用。代谢综合征组受试者的哮喘样症状（喘息[p = 0.0006]、静息性呼吸困难[p = 0.0062]和运动后呼吸困难[p < 0.0001]）有所增加。与没有哮喘样症状的受试者相比，有哮喘样症状的受试者肺功能下降。在代谢综合征的组成部分中，腹部肥胖和高血压是哮喘样症状的危险因素。
代谢综合征与哮喘样症状有关。在代谢综合征的组成部分中，腹部肥胖和高血压是哮喘样症状的危险因素。
