局部应用环孢素A和丝裂霉素C注射作为预防原发性翼状胬肉复发的辅助治疗。
Topical cyclosporin A and mitomycin C injection as adjunctive therapy for prevention of primary pterygium recurrence.
作者信息
Ibáñez Miguela, Eugarrios Marcela F, Calderón Delmy I
机构信息
Centro Médico Puerta de Hierro, Guadalajara, Mexico.
出版信息
Ophthalmic Surg Lasers Imaging. 2009 May-Jun;40(3):239-44. doi: 10.3928/15428877-20090430-03.
BACKGROUND AND OBJECTIVE
The authors evaluated the results of topical cyclosporin A 1% and injected mitomycin C 0.01% use as adjunctive therapy for prevention of primary pterygium recurrence.
PATIENTS AND METHODS
Eighty eyes of 76 consecutive patients who had pterygium excision surgery in a prospective, interventional clinical trial received conjunctival autografting combined with an immediate postoperative 0.1-cc injection of 0.01% mitomycin C in caruncula were randomized into two groups: those who received postoperative topical application of cyclosporin A and those who did not.
RESULTS
The recurrence rate in patients who received topical application of postoperative cyclosporin A was 7.5% (3 of 40) compared with 17.5% (7 of 40) for patients who did not receive topical application of postoperative cyclosporin A (P = .31). An unexpected and significant finding in women was that those who received cyclosporin A had no recurrences (0 of 26), whereas those who did not receive cyclosporin A did (6 of 25; 24%) (P = .03).
CONCLUSION
Intracaruncular mitomycin C 0.01% and topical cyclosporin A 1% combined with conjunctival autograft is useful in reducing pterygium recurrence.
背景与目的
作者评估了局部应用1%环孢素A和结膜下注射0.01%丝裂霉素C作为辅助治疗预防原发性翼状胬肉复发的效果。
患者与方法
在一项前瞻性干预性临床试验中，76例连续行翼状胬肉切除手术的患者的80只眼，接受结膜自体移植联合术后立即在泪阜处注射0.1 cc 0.01%丝裂霉素C，并随机分为两组：一组术后局部应用环孢素A，另一组不应用。
结果
术后局部应用环孢素A的患者复发率为7.5%（40例中的3例），未应用术后局部环孢素A的患者复发率为17.5%（40例中的7例）（P = 0.31）。一个意外且显著的发现是，女性中应用环孢素A的患者无复发（26例中的0例），而未应用环孢素A的患者有复发（25例中的6例；24%）（P = 0.03）。
结论
结膜下注射0.01%丝裂霉素C和局部应用1%环孢素A联合结膜自体移植有助于降低翼状胬肉复发率。
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