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[梅毒与输血]

[Syphilis and blood transfusion].

作者信息

Serrano J

机构信息

Departamento de Hematología y Hemoterapia, Fundación Jiménez Díaz (Universidad Autónoma), Madrid.

出版信息

Sangre (Barc). 1991 Jun;36(3):211-5.

PMID:1948541
Abstract

Along 17 years (1973-1989), syphilis screening has been performed on 146,355 blood units in the author's blood bank. A total number of 143 positive results (confirmed by MHA-TP) was registered, which means an incidence of 0.097%. Of the total number of blood units, 31,529 came from professional donors, 51 of them (0.16%) being positive, while of the 114,826 blood units from voluntary donors 92 were positive (0.08%). With respect to voluntary donations, the highest incidence of positive reactions was found between 1980 and 1982, but this period registered also the highest number of blood units studied. Along this 17 year period 8 patients have received blood products with positive syphilis test. They were transfused on urgent request with fresh blood or platelet concentrates, the transfusion being performed before knowing the results of the screening for syphilis. No special measures were taken in 2 such cases, who died shortly after the transfusion on account of their disease. Two other were treated with penicillin at the time of transfusion. The remaining four patients received preventive penicillin. Even taking into account that positive screening tests are uncommon amongst blood donors, and that only under special circumstances the patients receiving contaminated blood may develop the illness, it seems advisable for every blood bank to perform the screening for syphilis on every blood donation.

摘要

在17年期间(1973 - 1989年),作者所在的血库对146,355个血液单位进行了梅毒筛查。共记录到143个阳性结果(经MHA - TP确认),这意味着发病率为0.097%。在所有血液单位中,31,529个来自职业献血者,其中51个(0.16%)呈阳性,而在114,826个来自自愿献血者的血液单位中,92个呈阳性(0.08%)。关于自愿献血,1980年至1982年期间阳性反应的发生率最高,但这一时期检测的血液单位数量也最多。在这17年期间,有8名患者接受了梅毒检测呈阳性的血液制品。他们因紧急需求输注了新鲜血液或血小板浓缩液,输血是在梅毒筛查结果出来之前进行的。在2例这种情况下未采取特殊措施,这两名患者在输血后不久因疾病死亡。另外两名患者在输血时接受了青霉素治疗。其余四名患者接受了预防性青霉素治疗。即使考虑到献血者中阳性筛查试验并不常见,而且只有在特殊情况下接受受污染血液的患者才可能患病,但似乎每个血库对每次献血进行梅毒筛查是可取的。

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引用本文的文献

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A cost-utility analysis of Treponema pallidum haemagglutination (TPHA) testing for syphilis screening of blood donors: is the TPHA test useful for syphilis screening in a blood centre?梅毒螺旋体血细胞凝集试验(TPHA)用于献血者梅毒筛查的成本效用分析:TPHA试验在血液中心用于梅毒筛查是否有用?
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