Khawaja Nuzhat Parveen, Rehman Rakhshanda
Department of Obstetrics and Gynaecoloyg, Fatima Jinnah Medical College/Sir Ganga Ram Hospital, Lahore.
J Coll Physicians Surg Pak. 2009 Jun;19(6):359-62.
To compare the efficacy and safety of oral versus vaginal administration of misoprostol for second trimester pregnancy termination.
Interventional, quasi experimental study.
The Department of Obstetrics and Gynaecology Unit-II, Fatima Jinnah Medical College/Sir Ganga Ram Hospital, Lahore, from August, 2003 to October, 2004.
Sixty pregnant women at second trimester of gestation who were candidates for therapeutic termination of pregnancy were recruited for the study. Grandmultipara, women who had scarred uterus and history of hypersensitivity to prostaglandins were excluded. The subjects were assigned into two groups. Group 1 (n=30) had misoprostol orally, while the group 2 (n=30) received the drug by the vaginal route. Dosage regimen was similar in both groups that was 200 microg 4 hours apart till expulsion of fetus or maximum of upto 5 doses. Main outcome measures of the study were induction-expulsion interval, need for surgical evacuation and maternal complications.
The mean induction-expulsion interval in the group 1 and 2 was 11.8+/-8.3 and 12.8+/-8.5 hours respectively, which was not different statistically. The process of expulsion was complete in 53.3% of subjects in both groups by misoprostol only, while 36.6% required surgical evacuation in oral group versus 33.3% in vaginal group. The rate of failed induction in groups 1 and 2 was 10% and 13.3% respectively. There was no reported case of nausea, diarrhea, headache, dizziness, shivering, pyrexia and hyperstimulation in both the groups. However, a case of vomiting (3.3%) was observed in the vaginal group.
比较米索前列醇口服与阴道给药用于中期妊娠终止的疗效和安全性。
干预性、准实验性研究。
2003年8月至2004年10月，拉合尔市法蒂玛·真纳医学院/甘加·拉姆爵士医院妇产科第二单元。
招募60名中期妊娠且适合治疗性终止妊娠的孕妇进行研究。排除多产妇、子宫有瘢痕及对前列腺素过敏史的妇女。将受试者分为两组。第1组（n = 30）口服米索前列醇，第2组（n = 30）经阴道给药。两组给药方案相似，即每4小时服用200微克，直至胎儿排出或最多服用5剂。本研究的主要观察指标为引产至排出间隔时间、手术清宫需求及母体并发症。
第1组和第2组的平均引产至排出间隔时间分别为11.8±8.3小时和12.8±8.5小时，差异无统计学意义。两组中仅使用米索前列醇的情况下，53.3%的受试者排出过程完整，口服组36.6%需要手术清宫，阴道组为33.3%。第1组和第2组的引产失败率分别为10%和13.3%。两组均未报告恶心、腹泻、头痛、头晕、寒战、发热及过度刺激的病例。然而，阴道组观察到1例呕吐（3.3%）。
