Salla Juliana Tito, Johann Aline Cristina Batista Rodrigues, Garcia Bruna Gonçalves, Aguiar Maria Cássia Ferreira, Mesquita Ricardo Alves
Department of Oral Surgery, Medicine and Pathology, School of Dentistry, Federal University of Minas Gerais, MG, Brazil.
Braz Oral Res. 2009 Jan-Mar;23(1):43-8. doi: 10.1590/s1806-83242009000100008.
Traumatic neuroma, neurofibroma, neurilemmoma, palisaded encapsulated neuroma and malignant peripheral nerve sheath tumor (MPNST) are peripheral nerve sheath tumors and present neural origin. The goal of this study was to describe the epidemiological data of oral peripheral nerve sheath tumors in a sample of the Brazilian population. Biopsies requested from the Oral Pathology Service, School of Dentistry, Federal University of Minas Gerais (MG, Brazil), between 1966 and 2006 were evaluated. Lesions diagnosed as peripheral nerve sheath tumors were submitted to morphologic and to immunohistochemical analyses. All cases were immunopositive to the S-100 protein. Thirty-five oral peripheral nerve sheath tumors were found, representing 0.16% of all lesions archived in the Oral Pathology Service. Traumatic neuroma (15 cases) most frequently affected the mental foramen. Solitary neurofibroma (10 cases) was more frequently observed in the palate. Neurofibroma associated with neurofibromatosis type I (2 cases) was observed in the gingival and alveolar mucosa. Neurilemmoma (4 cases) was more commonly observed in the buccal mucosa. Malignant peripheral nerve sheath tumors (3 cases) occurred in the mandible, palate, and tongue. Palisaded encapsulated neuroma (1 case) occurred in the buccal mucosa. The data confirmed that oral peripheral nerve sheath tumors are uncommon in the oral region, with some lesions presenting a predilection for a specific gender or site. This study may be useful in clinical dentistry and oral pathology practice and may be used as baseline data regarding oral peripheral nerve sheath tumors in other populations.
创伤性神经瘤、神经纤维瘤、神经鞘瘤、栅栏状包膜神经瘤和恶性外周神经鞘瘤（MPNST）均为外周神经鞘瘤，起源于神经。本研究的目的是描述巴西人群样本中口腔外周神经鞘瘤的流行病学数据。对1966年至2006年间从米纳斯吉拉斯联邦大学牙科学院口腔病理科（巴西，米纳斯吉拉斯州）送检的活检标本进行评估。将诊断为外周神经鞘瘤的病变进行形态学和免疫组织化学分析。所有病例对S-100蛋白均呈免疫阳性。共发现35例口腔外周神经鞘瘤，占口腔病理科存档所有病变的0.16%。创伤性神经瘤（15例）最常累及颏孔。孤立性神经纤维瘤（10例）在腭部更为常见。与I型神经纤维瘤病相关的神经纤维瘤（2例）见于牙龈和牙槽黏膜。神经鞘瘤（4例）在颊黏膜更为常见。恶性外周神经鞘瘤（3例）发生于下颌骨、腭部和舌部。栅栏状包膜神经瘤（1例）发生于颊黏膜。数据证实口腔外周神经鞘瘤在口腔区域并不常见，一些病变在特定性别或部位有偏好。本研究可能对临床牙科和口腔病理学实践有用，并可作为其他人群口腔外周神经鞘瘤的基线数据。
