Desai Mina, Gayle Dave A, Casillas Ederlen, Boles Julie, Ross Michael G
Department of Obstetrics and Gynecology, David-Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, 90502, USA.
J Matern Fetal Neonatal Med. 2009 Jul;22(7):571-5. doi: 10.1080/14767050902874105.
We determined the impact of maternal food restriction during gestation and lactation or lactation alone on basal inflammation and lipopolysaccharide (LPS)-stimulated cytokine induction in adult female offspring.
From 10 days of gestation to term, pregnant rats received either ad libitum (control) feed or were 50% food restricted (FR). Pups were either nursed by their own dams or were cross-fostered to give three groups, namely, Control (AdLib/AdLib), FR during lactation (AdLib/FR) and FR during pregnancy and lactation (FR/FR). All offspring were weaned to ad libitum rat chow. At 9 months of age, basal inflammation and LPS-stimulated cytokine responsiveness were determined in female offspring.
The basal CRP levels were elevated in AdLib/FR and FR/FR as compared to Controls. In contrast, LPS induction of IL-1beta and IL-6 was significantly attenuated in the AdLib/FR and FR/FR offspring as compared to the Control group.
These findings suggest that early undernutrition, particularly during prenatal and postnatal periods, affects offspring immune competence by increasing basal inflammation while reducing cytokine induction to inflammatory stimuli.
我们确定了孕期和哺乳期或仅哺乳期母体食物限制对成年雌性后代基础炎症和脂多糖（LPS）刺激的细胞因子诱导的影响。
从妊娠第10天到足月，怀孕大鼠要么自由采食（对照）饲料，要么食物限制50%（FR）。幼崽要么由自己的母鼠哺乳，要么交叉寄养，从而形成三组，即对照组（自由采食/自由采食）、哺乳期食物限制组（自由采食/FR）和孕期及哺乳期食物限制组（FR/FR）。所有后代断奶后自由采食大鼠饲料。在9月龄时，测定雌性后代的基础炎症和LPS刺激的细胞因子反应性。
与对照组相比，自由采食/FR组和FR/FR组的基础CRP水平升高。相反，与对照组相比，自由采食/FR组和FR/FR组后代中LPS诱导的IL-1β和IL-6显著减弱。
这些发现表明，早期营养不良，特别是在产前和产后期间，通过增加基础炎症同时减少对炎症刺激的细胞因子诱导来影响后代的免疫能力。
