Transgeneration effects of antenatal acute hypoxia during early organogenesis.

作者信息

Dunaeva T Yu, Trofimova L K, Graf A V, Maslova M V, Maklakova A S, Krushinskaya Ya V, Sokolova N A

机构信息

Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.

出版信息

Bull Exp Biol Med. 2008 Oct;146(4):385-7. doi: 10.1007/s10517-009-0316-6.

We studied the effect of acute hypobaric hypoxia in early organogenesis on physiological and behavioral parameters of second-generation albino rats. Antenatal acute hypoxia was followed by physical and sexual retardation, increase in the mortality rate, and behavioral changes in second-generation animals (hypoactivity of males and females on day 22 of life and hyperactivity of males on day 57 of life). Second-generation animals exhibited no gender differences in body weight and horizontal and vertical locomotor activity.