Lu Zhimin, Hunter Tony
Department of Neuro-Oncology and Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer, Houston, TX 77030, USA.
Annu Rev Biochem. 2009;78:435-75. doi: 10.1146/annurev.biochem.013008.092711.
Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.
蛋白激酶是细胞内信号转导通路的重要调节因子,在多种细胞功能中发挥关键作用。一旦蛋白激酶被激活,其活性随后会通过多种机制被下调。越来越多的证据表明,蛋白激酶的激活通常通过泛素/蛋白酶体途径启动其下调过程。无法调节蛋白激酶的活性或表达水平会导致人类疾病。