Edwards Aled
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.
Annu Rev Biochem. 2009;78:541-68. doi: 10.1146/annurev.biochem.78.070907.103305.
The large-scale structural biology projects that target human proteins focus predominantly on the catalytic domains of potential therapeutic targets and the domains of human proteins that mediate protein-protein and protein-small-molecule interactions. Their main scientific objective is to elucidate the molecular basis for specificity and selectivity of function within large protein families of therapeutic interest, such as kinases, phosphatases, and proteins involved in epigenetic regulation. Half of the unique human protein structures determined in the past three years derive from these initiatives.
针对人类蛋白质的大规模结构生物学项目主要聚焦于潜在治疗靶点的催化结构域以及介导蛋白质-蛋白质和蛋白质-小分子相互作用的人类蛋白质结构域。其主要科学目标是阐明具有治疗意义的大型蛋白质家族（如激酶、磷酸酶和参与表观遗传调控的蛋白质）中功能特异性和选择性的分子基础。在过去三年中确定的独特人类蛋白质结构有一半来自这些项目。
