生物样本在纵向出生队列研究中的重要性。
The importance of biological samples in longitudinal birth cohort studies.
作者信息
Jones Richard
机构信息
Centre for Child and Adolescent Health, Department of Community Based Medicine, University of Bristol, Bristol, UK.
出版信息
Paediatr Perinat Epidemiol. 2009 Jul;23 Suppl 1:93-102. doi: 10.1111/j.1365-3016.2008.00999.x.
Abstract
Here we describe how measurements in biological samples can be used to provide direct measures of exposures to environmental pollutants, nutrients, infectious organisms and drugs of abuse, and to validate other less direct measures of exposure such as questionnaire responses. They can also be used as measures of outcome traits or intermediate phenotypes which may lie on the pathways to disease.
摘要
在此，我们描述了如何利用生物样本中的测量数据来直接测定对环境污染物、营养素、感染性生物以及滥用药物的暴露情况，并验证其他不太直接的暴露测量方法，如问卷调查结果。这些测量数据还可用于衡量可能处于疾病发生途径上的结局特征或中间表型。
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