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小儿整块肾移植给小儿受者。

Pediatric en bloc kidney transplantation into pediatric recipients.

作者信息

Lau Keith K, Berg Gerre M, Schjoneman Yolanda G, Perez Richard V, Butani Lavjay

机构信息

Department of Pediatrics, University of California, Davis, CA 95817, USA.

出版信息

Pediatr Transplant. 2010 Feb;14(1):100-4. doi: 10.1111/j.1399-3046.2009.01137.x. Epub 2009 Mar 11.

Abstract

As a result of the ongoing shortage in organ supply, en bloc renal transplantation from small donors has become more common for adult recipients with ESRD. However, because of concern for higher complication rates and sub-optimal outcomes, it is not being performed in every center, and data describing its use in pediatric recipients are even more limited. We retrospectively studied three patients who have undergone en bloc renal transplantation at our center. Median age at transplantation was 16.7 yr with a median follow-up of 1.2 yr. Donor age ranged from nine to 49 months with weight ranging from 10 to 22 kg. There were no post-operative thrombotic complications. All grafts showed increased renal size at follow-up by ultrasound. There was no clinical or histological rejection at last follow-up. To the best of our knowledge, this is the first report on the outcomes of en bloc kidney transplantation from pediatric donors into pediatric recipients. Based on our experience, albeit very limited, we feel that en bloc renal transplantation from young donors is an acceptable and safe procedure with low complication rates in pediatric recipients and should be given consideration to minimize wait times on the wait list and to improve quality of life.

摘要

由于目前器官供应短缺,对于终末期肾病的成年受者而言,来自小供体的整块肾移植变得更为常见。然而,由于担心并发症发生率更高以及预后欠佳,并非每个中心都开展此项手术,而且描述其在儿科受者中应用的数据更为有限。我们对在本中心接受整块肾移植的3例患者进行了回顾性研究。移植时的中位年龄为16.7岁,中位随访时间为1.2年。供体年龄为9至49个月,体重为10至22千克。术后无血栓形成并发症。随访时通过超声检查发现所有移植肾体积均增大。末次随访时无临床或组织学排斥反应。据我们所知,这是关于儿科供体向儿科受者进行整块肾移植结局的首份报告。基于我们尽管非常有限的经验,我们认为来自年轻供体的整块肾移植在儿科受者中是一种可接受且安全的手术,并发症发生率低,应予以考虑以尽量缩短等待名单上的等待时间并改善生活质量。

相似文献

1
Pediatric en bloc kidney transplantation into pediatric recipients.小儿整块肾移植给小儿受者。
Pediatr Transplant. 2010 Feb;14(1):100-4. doi: 10.1111/j.1399-3046.2009.01137.x. Epub 2009 Mar 11.
2
Outcome of renal transplants from pediatric donors <5 yr of age.5岁以下小儿供体肾移植的结果
Clin Transplant. 2005 Jun;19(3):316-20. doi: 10.1111/j.1399-0012.2005.00319.x.
4
Experience with dual kidney transplants from donors at the extremes of age.来自极端年龄供体的双肾移植经验。
Surgery. 2006 Oct;140(4):597-605; discussion 605-6. doi: 10.1016/j.surg.2006.07.004. Epub 2006 Aug 22.

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