改造脂肪代谢

Retrofitting fat metabolism.

作者信息

Pei Liming, Evans Ronald M

机构信息

Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

出版信息

Cell Metab. 2009 Jun;9(6):483-4. doi: 10.1016/j.cmet.2009.05.006.

DOI:10.1016/j.cmet.2009.05.006

PMID:19490901

Abstract

In this issue of Cell Metabolism, Liao and colleagues have applied a novel synthetic approach to fight obesity in animals by engineering the plant glyoxylate shunt in vivo (Dean et al., 2009). The idea of introducing an entirely foreign metabolic pathway opens up opportunities for understanding metabolism and creating novel potential therapeutic approaches.

摘要

在本期《细胞代谢》杂志中，廖及其同事应用了一种新颖的合成方法，通过在动物体内构建植物乙醛酸循环途径来对抗肥胖（迪恩等人，2009年）。引入全新的外源代谢途径这一想法为理解新陈代谢以及创造新的潜在治疗方法带来了机遇。