White Morris F
Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Cell Metab. 2009 Jun;9(6):485-7. doi: 10.1016/j.cmet.2009.05.007.
A recent Cell paper by He et al. (2009) shows how metformin circumvents a block between insulin and atypical protein kinase C in obese and diabetic mice to inhibit gluconeogenesis by stimulating the phosphorylation of CBP and the disassembly of the CREB transcriptional complex.
何等人（2009年）近期发表于《细胞》杂志的一篇论文展示了二甲双胍如何在肥胖和糖尿病小鼠中绕过胰岛素与非典型蛋白激酶C之间的障碍，通过刺激CBP的磷酸化和CREB转录复合物的解体来抑制糖异生。
