Farooqi Sadaf
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Cell Metab. 2009 Jun;9(6):487-8. doi: 10.1016/j.cmet.2009.05.008.
Maternal inheritance of mutations in the GNAS1 gene is associated with obesity in humans, but the mechanism involved is unknown. In this issue, Chen et al. (2009) have generated mice with brain specific deletion of either the maternal or paternal allele to trace the origin of the phenotype.
GNAS1基因突变的母系遗传与人类肥胖有关，但其涉及的机制尚不清楚。在本期中，Chen等人（2009年）构建了母本或父本等位基因在大脑中特异性缺失的小鼠，以追踪该表型的起源。
