Zolgharni M, Ledger P D, Armitage D W, Holder D S, Griffiths H
School of Medicine, Swansea University, Swansea, SA2 8PP, UK.
Physiol Meas. 2009 Jun;30(6):S187-200. doi: 10.1088/0967-3334/30/6/S13. Epub 2009 Jun 2.
Magnetic induction tomography (MIT) is a new electromagnetic imaging modality which has the potential to image changes in the electrical conductivity of the brain due to different pathologies. In this study the feasibility of detecting haemorrhagic cerebral stroke with a 16-channel MIT system operating at 10 MHz was investigated. The finite-element method combined with a realistic, multi-layer, head model comprising 12 different tissues, was used for the simulations in the commercial FE package, Comsol Multiphysics. The eddy-current problem was solved and the MIT signals computed for strokes of different volumes occurring at different locations in the brain. The results revealed that a large, peripheral stroke (volume 49 cm(3)) produced phase changes that would be detectable with our currently achievable instrumentation phase noise level (17 m degrees ) in 70 (27%) of the 256 exciter/sensor channel combinations. However, reconstructed images showed that a lower noise level than this, of 1 m degrees , was necessary to obtain good visualization of the strokes. The simulated MIT measurements were compared with those from an independent transmission-line-matrix model in order to give confidence in the results.
磁感应断层扫描(MIT)是一种新型电磁成像方式,它有潜力对因不同病变导致的大脑电导率变化进行成像。在本研究中,对使用工作频率为10 MHz的16通道MIT系统检测出血性脑中风的可行性进行了研究。在商业有限元软件包Comsol Multiphysics中,采用有限元方法并结合包含12种不同组织的真实多层头部模型进行模拟。求解了涡流问题,并计算了大脑不同位置出现的不同体积中风的MIT信号。结果显示,一个大的外周中风(体积为49立方厘米)产生的相位变化,在256个激励器/传感器通道组合中的70个(27%)中,以我们目前可实现的仪器相位噪声水平(17毫度)是可检测到的。然而,重建图像表明,要获得中风的良好可视化效果,需要低于此水平的1毫度噪声。将模拟的MIT测量结果与独立传输线矩阵模型的测量结果进行比较,以增强对结果的信心。