Ni Chunhui, Ye Yang, Wang Meilin, Qian Haiyang, Song Zhifang, Jia Xiaomin, Zhou Jianwei
Departments of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing, China.
J Toxicol Environ Health A. 2009;72(11-12):712-6. doi: 10.1080/15287390902841102.
Coal workers' pneumoconiosis (CWP) is a chronic interstitial lung disease with a complex etiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single-nucleotide polymorphisms (SNP) within CASPASE-8 (CASP8) promoter involved in resolution of inflammatory processes modulate the risk of CWP development. The study population consisted of 619 underground coal miners in the 5 coal mines of Xuzhou Mining Business Group Co. Ltd., China, of whom 315 were diagnosed with CWP. The association study between CASP8 -652 6N ins/del polymorphism with CWP by multiple logistic regression analysis showed a significant association of the genotype del/del with CWP compared with to ins/ins genotypes, and showed that the risk was significantly higher for stage I CWP. Further analysis showed that in subjects with the del/del genotype there was significantly increased risk for CWP occurrence among younger individuals (<66 yr) or those with longer duration dust exposure (>or=26 yr). These findings suggested that CASP8-652 6N ins/del polymorphism may contribute to the genetic susceptibility for CWP development.
煤工尘肺（CWP）是一种慢性间质性肺疾病，病因复杂，累积接触粉尘后可能发病。开展了一项病例对照研究，以检验以下假设：参与炎症过程消退的半胱天冬酶8（CASP8）启动子内的单核苷酸多态性（SNP）可调节CWP发生风险。研究人群包括中国徐州矿业集团有限公司5个煤矿的619名井下煤矿工人，其中315人被诊断为CWP。通过多因素逻辑回归分析对CASP8 -652 6N插入/缺失多态性与CWP进行关联研究，结果显示，与插入/插入基因型相比，缺失/缺失基因型与CWP存在显著关联，且I期CWP的风险显著更高。进一步分析表明，在缺失/缺失基因型个体中，年龄较小（<66岁）或粉尘接触时间较长（≥26年）的个体发生CWP的风险显著增加。这些发现提示，CASP8-652 6N插入/缺失多态性可能与CWP发生的遗传易感性有关。
