Søndergaard J O, Bülow S, Lynge E
Kraeftens Bekaempelse, Cancerregisteret, København.
Ugeskr Laeger. 1991 Sep 16;153(38):2624-6.
In order to investigate the influence of a possible genetic factor on the development of colorectal cancer (KRC), a cohort investigation was carried out among parents of patients with KRC. A total of 1,542 patients participated in the investigation. These patients were under the age of 60 years and registered in The Danish Cancer Register as cases of KRC during the period 1982-1984. 96% of the parents of these patients were identified by means of the administrative registers. The parents were then sought in The Danish Cancer Register for cancer during the period 1943-1986. The incidence rates for the Danish population were employed to calculate anticipated number of cases of KRC among these parents. significantly increased frequencies of KRC were found among both the mothers and the fathers, as the standardised incidence ratio was 1.62 in mothers and 1.87 among fathers. As a Danish investigation of spouses of patients with KRC has not demonstrated any increased frequency of KRC among spouses, it is concluded that this finding indicates a possible genetic factor in the etiology of KRC.
为了研究可能的遗传因素对结直肠癌（KRC）发病的影响，对KRC患者的父母进行了一项队列研究。共有1542名患者参与了该研究。这些患者年龄在60岁以下，于1982年至1984年期间在丹麦癌症登记处登记为KRC病例。通过行政登记识别出了这些患者中96%的父母。随后在丹麦癌症登记处查找这些父母在1943年至1986年期间患癌症的情况。采用丹麦人口的发病率来计算这些父母中KRC的预期病例数。在母亲和父亲中均发现KRC的频率显著增加，母亲的标准化发病率为1.62，父亲为1.87。由于丹麦对KRC患者配偶的一项调查未显示配偶中KRC的频率有任何增加，因此得出结论，这一发现表明KRC病因中可能存在遗传因素。
