Department of Neonatology, Children's Hospital, University of Bonn, Germany.
J Perinat Med. 2009;37(5):535-8. doi: 10.1515/JPM.2009.097.
Meconium peritonitis (MP) is a rare prenatal condition that leads to substantial neonatal morbidity and mortality.
All patients between 1998 and 2006 referred for prenatal diagnosis were retrospectively analyzed for diagnosis of MP. Prenatal ultrasound findings were compared with postnatal etiology, intraoperative findings, and postnatal outcome of the patients.
Antenatal MP was diagnosed in 14 fetuses between 18 and 38 weeks' gestation. The prenatal diagnosis of MP was confirmed by clinical and radiological findings in 8 (62%) of 13 infants born alive. All patients were delivered preterm between 33 and 36 weeks' gestation by cesarean section. Urgent neonatal surgery for treatment of bowel obstruction was required in all eight infants. Prenatal ultrasound diagnosis of bowel dilatation was the only variable found to be associated with the need for subsequent surgical intervention (P=0.02).
Clinical outcome of MP diagnosed antenatally can be either mild or severe form. The underlying cause of severe MP is heterogeneous and neonatal surgery was always required.
胎粪性腹膜炎（MP）是一种罕见的产前疾病，可导致新生儿发病率和死亡率显著增加。
对 1998 年至 2006 年间所有因产前诊断而转诊的患者进行回顾性分析，以诊断 MP。比较了产前超声检查结果与患儿的产后病因、术中所见和产后结局。
在 18 至 38 周妊娠的 14 例胎儿中诊断出产前 MP。13 例活产儿中有 8 例（62%）通过临床和影像学检查确诊为 MP。所有患儿均通过剖宫产在 33 至 36 周之间早产。所有 8 例患儿均因肠梗阻需要紧急新生儿手术治疗。产前超声诊断肠扩张是唯一与后续手术干预相关的变量（P=0.02）。
产前诊断的 MP 临床结局可能为轻度或重度。重度 MP 的潜在病因是异质的，新生儿手术总是需要的。
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