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地拉罗司所致范科尼综合征

Fanconi syndrome due to deferasirox.

作者信息

Rafat Cédric, Fakhouri Fadi, Ribeil Jean-Antoine, Delarue Richard, Le Quintrec Moglie

机构信息

Université Paris Descartes, Hôpital Necker, APHP, Paris, France.

出版信息

Am J Kidney Dis. 2009 Nov;54(5):931-4. doi: 10.1053/j.ajkd.2009.03.013. Epub 2009 Jun 3.

Abstract

Deferasirox is an innovative iron-chelating treatment. However, preliminary data have suggested that kidney toxicity may be a major issue in the management of patients receiving this drug. We report a case of Fanconi syndrome associated with acute renal insufficiency in a patient receiving deferasirox. The latter has to be added to the expanding list of drugs that may induce Fanconi syndrome. Careful monitoring of kidney function and markers of proximal tubular injury are mandatory in patients undergoing treatment with deferasirox.

摘要

地拉罗司是一种创新的铁螯合治疗药物。然而,初步数据表明,肾毒性可能是接受该药物治疗患者管理中的一个主要问题。我们报告了1例接受地拉罗司治疗的患者出现范科尼综合征并伴有急性肾功能不全的病例。地拉罗司必须被列入可能诱发范科尼综合征的药物清单中。接受地拉罗司治疗的患者必须仔细监测肾功能和近端肾小管损伤标志物。

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