细胞对骨形态发生蛋白及其衍生肽的反应：生物医学应用与局限性
Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations.
作者信息
Senta H, Park H, Bergeron E, Drevelle O, Fong D, Leblanc E, Cabana F, Roux S, Grenier G, Faucheux N
机构信息
Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, QC, Canada.
出版信息
Cytokine Growth Factor Rev. 2009 Jun;20(3):213-22. doi: 10.1016/j.cytogfr.2009.05.006. Epub 2009 Jun 2.
The bone morphogenetic proteins (BMPs) are cytokines of the transforming growth factor beta family. Some BMPs such as BMP-2 and BMP-7 play a major role in the development of the skeleton and the maintenance of homeostasis during bone remodelling. To date, only BMP-2 and BMP-7 have been approved by the Food and Drug Administration for specific orthopaedic applications. However, due to BMP cost, peptides derived from their knuckle epitope with osteogenic properties have been developed. BMPs are involved in many other biological events, including embryogenesis, angiogenesis and cancer. BMPs therefore have great biomedical potential as osteogenic factors and as anti-cancer agents. This review focuses on the use of BMPs and their derived peptides in biomedical delivery systems and gene therapy.
骨形态发生蛋白（BMPs）是转化生长因子β家族的细胞因子。一些BMPs，如BMP-2和BMP-7，在骨骼发育和骨重塑过程中的稳态维持中起主要作用。迄今为止，只有BMP-2和BMP-7已被美国食品药品监督管理局批准用于特定的骨科应用。然而，由于BMP成本较高，已开发出具有成骨特性的源自其指关节表位的肽。BMPs还参与许多其他生物学事件，包括胚胎发生、血管生成和癌症。因此，BMPs作为成骨因子和抗癌剂具有巨大的生物医学潜力。本综述重点关注BMPs及其衍生肽在生物医学递送系统和基因治疗中的应用。
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