In vitro intravesical instillation of anticholinergic, antispasmodic and calcium blocking agents to decrease bladder contractility.

We investigated the effect of intravesical administration of atropine, oxybutynin, verapamil, diltiazem, and imipramine on pressure responses of the rabbit in vitro whole bladder model. All drugs investigated suppressed the pressure responses to field stimulation and bethanechol in a time-dependent manner (maximum inhibition at 90-120 min). Atropine and oxybutynin suppressed the contractile response to bethanechol to a much greater extent than that to field stimulation. These results suggest that the use of self-intravesical instillation might be a good therapeutic approach for patients with detrusor hyperreflexia, especially those who are already managed by intermittent catheterization.