Cardif介导的信号传导在体内控制对登革热病毒的初始固有反应。
Cardif-mediated signaling controls the initial innate response to dengue virus in vivo.
作者信息
Perry Stuart T, Prestwood Tyler R, Lada Steven M, Benedict Chris A, Shresta Sujan
机构信息
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
出版信息
J Virol. 2009 Aug;83(16):8276-81. doi: 10.1128/JVI.00365-09. Epub 2009 Jun 3.
Abstract
The role of Cardif-dependent signaling in controlling dengue virus (DENV) infection and regulating type I interferon (IFN) production in vivo was examined in Cardif-deficient mice. DENV RNA levels were significantly elevated in both the serum and lymphoid tissues of Cardif(-/-) mice at early times compared to those in wild-type animals. Type I IFN production was delayed in these locales of Cardif(-/-) mice until 18 h postinfection, indicating that Cardif regulates the initial type I IFN response in lymphoid tissues. In contrast, DENV viral loads in nonlymphoid tissues were similar between Cardif(-/-) and wild-type mice. These results reveal that RNA helicase-mediated sensing acts as a first line of innate defense against DENV infection in vivo and functions in a tissue-dependent manner.
摘要
在Cardif基因缺陷小鼠中研究了依赖Cardif的信号传导在体内控制登革病毒（DENV）感染和调节I型干扰素（IFN）产生中的作用。与野生型动物相比，在早期，Cardif（-/-）小鼠的血清和淋巴组织中的DENV RNA水平均显著升高。Cardif（-/-）小鼠这些部位的I型干扰素产生延迟至感染后18小时，表明Cardif调节淋巴组织中的初始I型干扰素反应。相比之下，Cardif（-/-）小鼠和野生型小鼠非淋巴组织中的DENV病毒载量相似。这些结果表明，RNA解旋酶介导的传感作为体内针对DENV感染的先天性防御的第一道防线，并以组织依赖的方式发挥作用。
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