评估1型人类免疫缺陷病毒嗜性：使用具有复制能力的病毒与血浆来源的假型病毒体的检测方法比较。
Assessing human immunodeficiency virus type 1 tropism: Comparison of assays using replication-competent virus versus plasma-derived pseudotyped virions.
作者信息
Hosoya Noriaki, Su Zhaohui, Wilkin Timothy, Gulick Roy M, Flexner Charles, Hughes Michael D, Skolnik Paul R, Giguel Françoise, Greaves Wayne L, Coakley Eoin, Kuritzkes Daniel R
机构信息
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Clin Microbiol. 2009 Aug;47(8):2604-6. doi: 10.1128/JCM.00632-09. Epub 2009 Jun 3.
Abstract
Detection of CXCR4-using human immunodeficiency virus by the Trofile assay was compared to that by assays using virus isolates or replication-competent recombinants. Concordance with the Trofile assay was good, but assays using replicating viruses did not increase substantially the ability to detect the presence of CXCR4-using virus.
摘要
通过Trofile检测法检测使用CXCR4的人类免疫缺陷病毒，并与使用病毒分离株或具有复制能力的重组体的检测法进行比较。与Trofile检测法的一致性良好，但使用复制病毒的检测法并未显著提高检测使用CXCR4病毒存在的能力。
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