Hardarson Sveinn Hakon, Gottfredsdottir Maria Soffia, Halldorsson Gisli Hreinn, Karlsson Robert Arnar, Benediktsson Jon Atli, Eysteinsson Thor, Beach James M, Harris Alon, Stefansson Einar
Department of Ophthalmology, University of Iceland/Landspítali-University Hospital, Reykjavik, Iceland.
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5247-50. doi: 10.1167/iovs.08-3117. Epub 2009 Jun 3.
Glaucoma may involve disturbances in retinal oxygenation and blood flow. The purpose of this study was to measure the effect of glaucoma filtration surgery on retinal vessel oxygen saturation.
A noninvasive spectrophotometric retinal oximeter was used to measure hemoglobin oxygen saturation in retinal arterioles and venules before and after glaucoma filtration surgery. Twenty-five consecutive patients were recruited, and 19 had adequate image quality. Fourteen underwent trabeculectomy and five glaucoma tube surgery. Twelve had primary open-angle glaucoma and seven had exfoliative glaucoma. IOP decreased from 23 +/- 7 to 10 +/- 4 mm Hg (mean +/- SD, P = 0.0001).
Oxygen saturation increased in retinal arterioles from 97% +/- 4% to 99% +/- 6% (n = 19; P = 0.046) after surgery and was unchanged in venules (63% +/- 5% before surgery and 64% +/- 6% after, P = 0.76). There were no significant changes in saturation in the fellow eyes (P > 0.60). The arteriovenous difference was 34% before and 36% after surgery (P = 0.35).
Glaucoma filtration surgery had almost no effect on retinal vessel oxygen saturation.
青光眼可能涉及视网膜氧合和血流的紊乱。本研究的目的是测量青光眼滤过手术对视网膜血管氧饱和度的影响。
使用无创分光光度视网膜血氧计测量青光眼滤过手术前后视网膜小动脉和小静脉中的血红蛋白氧饱和度。连续招募了25名患者，其中19名图像质量良好。14名接受了小梁切除术，5名接受了青光眼引流管手术。12名患有原发性开角型青光眼，7名患有剥脱性青光眼。眼压从23±7降至10±4 mmHg（平均值±标准差，P = 0.0001）。
术后视网膜小动脉中的氧饱和度从97%±4%增加到99%±6%（n = 19；P = 0.046），而小静脉中的氧饱和度没有变化（术前63%±5%，术后64%±6%，P = 0.76）。对侧眼的饱和度没有显著变化（P > 0.60）。手术前后动静脉血氧饱和度差值分别为34%和36%（P = 0.35）。
青光眼滤过手术对视网膜血管氧饱和度几乎没有影响。
