前沿：CD19 缺陷对边缘区细胞的原发性和继发性影响。
Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone.
作者信息
You Yuying, Zhao Hong, Wang Yue, Carter Robert H
机构信息
Department of Microbiology, University of Alabama at Birmingham, Birmingham AL 35294, USA.
出版信息
J Immunol. 2009 Jun 15;182(12):7343-7. doi: 10.4049/jimmunol.0804295.
Abstract
Marginal zone (MZ) B cells are absent in CD19(-/-) mice. Possible causes include an intrinsic defect in B cells and/or a secondary defect in the extrinsic MZ microenvironment as a result of changes in B cell differentiation in mice lacking CD19. Cells in the MZ also include MZ macrophages (MZM) and MZ dendritic cells (DC). Although CD19 is only expressed on B cells, SIGN-R1(+) MZM are absent and CD11c(+) MZ DC distribution is abnormal in CD19(-/-) mice. Adoptively transferred B cells from normal mice are able to reconstitute MZ B cells in CD19(-/-) mice. In contrast, CD19(-/-) B cells could not enter the MZ of the normal mice. Furthermore, MZM distribution and MZ DC distribution are restored following MZ B cell reconstitution in CD19(-/-) mice. Thus, MZ B cells are required for MZM differentiation and MZ DC localization, but the deficiency of MZ B cells in CD19(-/-) mice is caused by a defect of intrinsic B cell signaling.
摘要
边缘区（MZ）B细胞在CD19基因敲除（-/-）小鼠中缺失。可能的原因包括B细胞的内在缺陷和/或由于缺乏CD19的小鼠B细胞分化变化导致的外在MZ微环境的继发性缺陷。MZ中的细胞还包括MZ巨噬细胞（MZM）和MZ树突状细胞（DC）。尽管CD19仅在B细胞上表达，但在CD19（-/-）小鼠中，SIGN-R1（+）MZM缺失且CD11c（+）MZ DC分布异常。从正常小鼠过继转移的B细胞能够在CD19（-/-）小鼠中重建MZ B细胞。相反，CD19（-/-）B细胞无法进入正常小鼠的MZ。此外，在CD19（-/-）小鼠中重建MZ B细胞后，MZM分布和MZ DC分布得以恢复。因此，MZ B细胞是MZM分化和MZ DC定位所必需的，但CD19（-/-）小鼠中MZ B细胞的缺乏是由内在B细胞信号传导缺陷引起的。
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