Witowski Janusz, Jörres Achim
Contrib Nephrol. 2009;163:27-34. doi: 10.1159/000223777. Epub 2009 Jun 3.
During chronic peritoneal dialysis (PD), the peritoneal membrane undergoes structural and functional alterations that, in some patients, may eventually lead to loss of function as the 'dialysis membrane'. These alterations include loss of mesothelial cells, thickening of the submesothelial compact zone, and changes of vascularization. At least some of these effects are thought to be associated with chronic exposure to unphysiological PD fluids. On a cellular level, chronic PD is associated with the phenomenon of epithelial-to-mesenchymal transformation (EMT) as well as premature aging and senescence of mesothelial cells. The present article discusses the potential mechanisms involved in these phenomena and reviews the current information derived from cell culture and animal studies.
在慢性腹膜透析（PD）过程中，腹膜会发生结构和功能改变，在一些患者中，这些改变最终可能导致作为“透析膜”的功能丧失。这些改变包括间皮细胞丢失、间皮下致密层增厚以及血管化改变。至少其中一些影响被认为与长期接触非生理性腹膜透析液有关。在细胞水平上，慢性腹膜透析与上皮-间充质转化（EMT）现象以及间皮细胞过早衰老和衰老有关。本文讨论了这些现象所涉及的潜在机制，并综述了来自细胞培养和动物研究的当前信息。
