Calhoun David A
Expert Opin Pharmacother. 2009 Aug;10(12):1869-74. doi: 10.1517/14656560902980210.
The use of antihypertensive therapy is an evolving paradigm. Although blood pressure (BP) control rates remain low, there have been improvements that may be attributable in part to a recent shift in clinical guidelines that recognizes that most patients will require multiple drugs to reach BP goals and encourages clinicians to use combination therapy as first-line treatment in selected patients. Single-pill combinations of two complementary antihypertensive medications offer benefits beyond those of separate administration of the individual component agents, providing a simpler medication regimen that is effective and well tolerated while enhancing patient adherence to therapy. In the future, there may be single-pill combinations of three antihypertensive drugs to further enhance BP control rates.
抗高血压治疗的应用是一个不断发展的模式。尽管血压（BP）控制率仍然较低，但已经有所改善，这部分可能归因于临床指南最近的转变，该转变认识到大多数患者需要多种药物才能达到血压目标，并鼓励临床医生在特定患者中使用联合治疗作为一线治疗。两种互补抗高血压药物的单片复方制剂提供了比单独使用各成分药物更多的益处，提供了一种更简单的药物治疗方案，既有效又耐受性良好，同时提高了患者对治疗的依从性。未来，可能会有三种抗高血压药物的单片复方制剂，以进一步提高血压控制率。
