Shutenko Zh V, Priedena I A, Kalvin'sh I Ia, Lukevits E Ia
Vopr Med Khim. 1991 May-Jun;37(3):24-6.
Inhibitor of carnitine-dependent metabolism mildronate, 3-(2,2,2-trimethylhydrazinium) propionate, administered into rats at a dose of 200 mg/kg, per os, within 10 days, caused a decrease in concentration of free carnitine and of long-chain acylcarnitine in myocardium as well as contributed to accumulation of free fatty acids in blood serum. Besides, the rate of I-14C-palmitic acid turnover to 14CO2 was decreased in myocardium homogenate. The drug inhibitory effect on carnitine biosynthesis from gamma-butyrobetaine was responsible for the phenomenon observed. Content of the metabolites studied was altered gradually both during treatment of rats with mildronate and after the drug abolition, thus demonstrating an opportunity of gentle influence on carnitine-dependent metabolism by means of the drug treatment and its abolition.
肉碱依赖性代谢抑制剂米屈肼（3-(2,2,2-三甲基肼基)丙酸酯）以200mg/kg的剂量经口给予大鼠，持续10天，导致心肌中游离肉碱和长链酰基肉碱浓度降低，并促使血清中游离脂肪酸积累。此外，心肌匀浆中I-14C-棕榈酸向14CO2的周转速率降低。该药物对γ-丁酸甜菜碱合成肉碱的抑制作用导致了所观察到的现象。在用米屈肼治疗大鼠期间以及停药后，所研究代谢物的含量均逐渐改变，从而表明通过药物治疗及其停用对肉碱依赖性代谢进行温和影响的可能性。
