HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.

作者信息

Wang Guangyi, Zhang Laiguo, Wu Xiaomin, Das Debasis, Ruhrmund Donald, Hooi Lisa, Misialek Shawn, Ravi Rajagopalan P T, Buckman Brad O, Kossen Karl, Seiwert Scott D, Beigelman Leonid

机构信息

Discovery Research, InterMune, Inc., Brisbane, CA 94005, USA.

出版信息

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4484-7. doi: 10.1016/j.bmcl.2009.05.021. Epub 2009 May 9.

DOI:10.1016/j.bmcl.2009.05.021

PMID:19497737

Abstract

3-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.

摘要

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