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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.

作者信息

Wang Guangyi, Lei Huoxing, Wang Xiaofang, Das Debasis, Hong Jian, Mackinnon Colin H, Coulter Thomas S, Montalbetti Christian A G N, Mears Richard, Gai Xinjie, Bailey Sarah E, Ruhrmund Donald, Hooi Lisa, Misialek Shawn, Rajagopalan P T Ravi, Cheng Robert K Y, Barker John J, Felicetti Brunella, Schönfeld Dorian L, Stoycheva Antitsa, Buckman Brad O, Kossen Karl, Seiwert Scott D, Beigelman Leonid

机构信息

Discovery Research, InterMune, Inc., Brisbane, CA 94005, USA.

出版信息

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. doi: 10.1016/j.bmcl.2009.05.022. Epub 2009 May 9.

DOI:10.1016/j.bmcl.2009.05.022
PMID:19500983
Abstract

(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.

摘要

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