意大利注射吸毒者中丙型肝炎病毒基因型流行率的变化——与开始注射的时间段的关系
Changes in the prevalence of hepatitis C virus genotype among Italian injection drug users-relation to period of injection started.
作者信息
Sereno Silvia, Perinelli Paola, Laghi Vittorio
机构信息
Department of Infectious and Tropical Diseases, University La Sapienza, Viale del Policlinico, 00161 Rome, Italy.
出版信息
J Clin Virol. 2009 Aug;45(4):354-7. doi: 10.1016/j.jcv.2009.04.022. Epub 2009 Jun 3.
BACKGROUND
Chronic hepatitis C is a worldwide health problem. Intravenous drug users are the main risk group.
OBJECTIVES
To determine the prevalence of HCV genotypes in Italian injecting drug users and the distribution of genotypes in relation to the period when the infection was acquired.
STUDY DESIGN
Two hundred sera from patients with chronic hepatitis C and a history of intravenous drug use were assayed for HCV-RNA and genotyped by a commercial line probe assay.
RESULTS
Genotypes 1 (45.5%) and 3 (35%) were the most common genotypes, followed by genotypes 4 (15%) and 2 (3%). One genotype 5 (0.5%) was found. Two mixed infections (1%) were detected. Subtype could be determined in 160 cases (80%): subtype 3a was the most prevalent (41.3%), followed by subtypes 1a (23.1%) and 1b (20.6%). A significant change in the distribution of prevalent genotypes occurred since 1965 (p=0.020). Genotype 3 infections declined from 48/116 (41.4%) in 1965-1985 to 22/84 (26.2%) in 1986-2006. The prevalence of genotype 4 was significantly higher in patients infected after 1985 compared to patients infected before this year (11/116 [9.5%] vs. 19/84 [22.6%], respectively; p=0.018).
CONCLUSIONS
Since 1965 the common HCV genotype 3 has become less common in Italy. Genotype 4, an imported genotype, has become more common.
背景
慢性丙型肝炎是一个全球性的健康问题。静脉注射吸毒者是主要的风险群体。
目的
确定意大利注射吸毒者中HCV基因型的流行情况以及基因型与感染获得时期的分布关系。
研究设计
对200例有慢性丙型肝炎病史且有静脉注射吸毒史患者的血清进行HCV-RNA检测，并通过商业线性探针分析法进行基因分型。
结果
基因型1（45.5%）和3（35%）是最常见的基因型，其次是基因型4（15%）和2（3%）。发现1例基因型5（0.5%）。检测到2例混合感染（1%）。160例（80%）可确定亚型：3a亚型最常见（41.3%），其次是1a亚型（23.1%）和1b亚型（20.6%）。自1965年以来，流行基因型的分布发生了显著变化（p = 0.020）。基因型3感染从1965 - 1985年的48/116（41.4%）降至1986 - 2006年的22/84（26.2%）。1985年后感染的患者中基因型4的流行率显著高于该年份之前感染的患者（分别为11/116 [9.5%]和19/84 [22.6%]；p = 0.018）。
结论
自1965年以来，常见的HCV基因型3在意大利变得不那么常见。基因型4，一种输入性基因型，变得更加常见。
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