意大利南部丙型肝炎病毒（HCV）基因型 9 年分布模式。
Nine-year distribution pattern of hepatitis C virus (HCV) genotypes in Southern Italy.
机构信息
SSD Virology and Molecular Biology, Department of Diagnostic Area, Istituto Nazionale Tumori, Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
Transfusion Service, Department of Hemathology, Istituto Nazionale Tumori-Fondazione "G. Pascale", IRCCS Italia, Naples, Italy.
出版信息
PLoS One. 2019 Feb 20;14(2):e0212033. doi: 10.1371/journal.pone.0212033. eCollection 2019.
INTRODUCTION
It has been greatly described that different hepatitis C virus (HCV) genotypes are strictly correlated to various evolution, prognosis and response to therapy during the chronic liver disease. Aim of this study was to outline the changes in the epidemiology of Hepatitis C genotypes in Southern Italy regions from 2006 to 2014.
MATERIAL/METHODS: Prevalence of HCV genotypes was analyzed in 535 HCV-RNA positive patients with chronic Hepatitis C infection, selected during the period 2012-2014, and compared with our previous data, referred to periods 2006-2008 and 2009-2011.
RESULTS
In all the three periods analyzed, genotype 1b is predominant (51.8% in 2006-08, 48.3% in 2009-11 and 54.4% in 2012-14) while genotype 2 showed an increase in prevalence (27.9% in 2006-08, 31.7% in 2009-11 and 35.2% in 2012-14) and genotypes 3a and 1a a decrease during the same period (6.8% in 2006-08, 4.7% in 2009-11 and 3.2% in 2012-14 and 7.9% in 2006-08, 4.7% in 2009-11 and 2.6% in 2012-14, respectively). Subtype 1b seems to be equally distributed between males and females (52.7% vs 56.6%) and the prevalence in the age range 31-40 years is significantly higher in the 2012-14 period than in both previous periods (53.8% vs. 16.6% in 2009-11, p< 0.001 and 13.4% in 2006-08, p < 0.001).
CONCLUSIONS
Genotype 1b is still the most prevalent, even if shows a significantly increase in the under 40 years old population. Instead, genotype 3a seems to have a moderate increase among young people. Overall, the alarming finding is the "returning" role of the iatrogenic transmission as risk factor for the diffusion of Hepatitis C infection.
简介
不同的丙型肝炎病毒（HCV）基因型与慢性肝病的演变、预后和治疗反应密切相关，这一点已得到充分描述。本研究旨在概述 2006 年至 2014 年意大利南部地区丙型肝炎基因型的流行病学变化。
材料/方法：对 2012-2014 年期间 535 例慢性丙型肝炎感染的 HCV-RNA 阳性患者的 HCV 基因型流行率进行了分析，并与我们之前的研究数据（2006-2008 年和 2009-2011 年）进行了比较。
结果
在所有三个分析期间，基因型 1b 均占优势（2006-08 年为 51.8%，2009-11 年为 48.3%，2012-14 年为 54.4%），而基因型 2 的流行率则有所增加（2006-08 年为 27.9%，2009-11 年为 31.7%，2012-14 年为 35.2%），同时基因型 3a 和 1a 的流行率则有所下降（2006-08 年为 6.8%，2009-11 年为 4.7%，2012-14 年为 3.2%，2006-08 年为 7.9%，2009-11 年为 4.7%，2012-14 年为 2.6%）。亚型 1b 在男性和女性中的分布比例大致相同（52.7%对 56.6%），在 2012-14 年期间，31-40 岁年龄组的患病率明显高于前两个时期（2009-11 年为 53.8%，与 16.6%相比，p<0.001；2006-08 年为 13.4%，p<0.001）。
结论
基因型 1b 仍然是最常见的，但在 40 岁以下人群中的比例显著增加。相反，基因型 3a 在年轻人中的比例似乎有所增加。总的来说，令人警惕的是医源性传播作为丙型肝炎感染传播的危险因素的“回归”作用。
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