Di Cera Enrico
Washington University, USA.
Blood. 2009 Jun 4;113(23):5699-700. doi: 10.1182/blood-2009-03-211292.
The mechanism underscoring efficacy of APC in the treatment of sepsis is still unresolved. The dual nature of APC as a potent antithrombotic and cytoprotective agent complicates the task, but in this issue of , Mosnier and colleagues offer a compelling solution and challenge the molecular underpinnings of APC function.
活化蛋白C(APC)治疗脓毒症的有效机制仍未明确。APC作为一种强效抗血栓形成和细胞保护剂的双重特性使这一问题变得复杂,但在本期杂志中,莫斯尼尔及其同事提出了一个令人信服的解决方案,并对APC功能的分子基础提出了质疑。