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Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT.

作者信息

Markey Kate A, MacDonald Kelli P A, Hill Geoffrey R

出版信息

Blood. 2009 Jun 4;113(23):6038-9. doi: 10.1182/blood-2009-03-212944.

DOI:10.1182/blood-2009-03-212944
PMID:19498034
Abstract
摘要

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Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT.骨髓移植后引发同种异体T细胞反应并不需要受体浆细胞样树突状细胞。
Blood. 2009 Jun 4;113(23):6038-9. doi: 10.1182/blood-2009-03-212944.
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Flt-3L Expansion of Recipient CD8α Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD.Flt-3L 扩增受体 CD8α 树突状细胞可清除同种异体反应性供者 T 细胞,是移植后环磷酰胺预防移植物抗宿主病的替代方法。
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Immunotherapy for malignant tumors using combination of allogeneic intra-bone marrow-bone marrow transplantation, donor lymphocyte infusion and dendritic cells.使用异基因骨髓内骨髓移植、供体淋巴细胞输注和树突状细胞联合治疗恶性肿瘤的免疫疗法。
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ICOSL plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist.ICOSL 浆细胞样树突状细胞作为移植物抗宿主病的诱导剂,对双重 ICOS/CD28 拮抗剂有反应。
Sci Transl Med. 2020 Oct 7;12(564). doi: 10.1126/scitranslmed.aay4799.
2
Epigenetic Regulation of Dendritic Cell Development and Function.树突状细胞发育与功能的表观遗传调控
Cancer J. 2017 Sep/Oct;23(5):302-307. doi: 10.1097/PPO.0000000000000280.
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DLL4 dendritic cells: Key regulators of Notch Signaling in effector T cell responses.
DLL4树突状细胞:效应T细胞反应中Notch信号的关键调节因子。
Pharmacol Res. 2016 Nov;113(Pt A):449-457. doi: 10.1016/j.phrs.2016.09.001. Epub 2016 Sep 14.
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Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice.Delta-like 配体 4 鉴定了一种以前尚未表征的炎症性树突状细胞群体,该群体在诱导小鼠同种异体 T 细胞反应中发挥重要作用。
J Immunol. 2013 Apr 1;190(7):3772-82. doi: 10.4049/jimmunol.1202820. Epub 2013 Feb 25.
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Biology of graft-versus-host responses: recent insights.移植物抗宿主反应的生物学:最新见解
Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S10-4. doi: 10.1016/j.bbmt.2012.11.005.
6
IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity.供者树突状细胞与 T 细胞之间的 IFN-γ 和吲哚胺 2,3-双加氧酶信号转导调节移植物抗宿主病和移植物抗白血病活性。
Blood. 2012 Jan 26;119(4):1075-85. doi: 10.1182/blood-2010-12-322891. Epub 2011 Nov 30.
7
Activation, immune polarization, and graft-versus-leukemia activity of donor T cells are regulated by specific subsets of donor bone marrow antigen-presenting cells in allogeneic hemopoietic stem cell transplantation.供者骨髓抗原呈递细胞的特定亚群调节同种异体造血干细胞移植中供者 T 细胞的激活、免疫极化和移植物抗白血病活性。
J Immunol. 2009 Dec 15;183(12):7799-809. doi: 10.4049/jimmunol.0900155.