Kopera H
International Health Foundation, Brüssel, Belgien.
Wien Med Wochenschr. 1991;141(15):346-8.
The first trials using oestrogen-containing substances to treat climacteric symptoms were performed as long ago as the end of the last century, when oestrogenic hormones were not yet even known to exist. However, it took a further 60 years or so before oestrogens and other sex hormones such as progestogens and androgens could be prepared in the form of acceptable hormonal drugs. Meanwhile, the use of such drugs and their artificial derivatives for the treatment of climacteric complaints and disorders and the prophylaxis of major postmenopausal diseases has been refined to such a high degree of safety and efficacy that these forms of therapy have become part of the essential medical armamentarium.
早在上个世纪末就进行了首次使用含雌激素物质治疗更年期症状的试验，而那时人们甚至还不知道雌激素的存在。然而，又过了大约60年，雌激素和其他性激素，如孕激素和雄激素，才得以制成可接受的激素药物形式。与此同时，使用这类药物及其人工衍生物治疗更年期不适和紊乱以及预防主要的绝经后疾病，已在安全性和有效性方面达到了很高的水平，以至于这些治疗方式已成为基本医疗手段的一部分。
