Korenaga D, Moriguchi S, Baba H, Kakeji Y, Orita H, Haraguchi M, Maehara Y, Ueo H, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
World J Surg. 1991 Sep-Oct;15(5):642-7; discussion 647-8. doi: 10.1007/BF01789215.
We report here the outcome of surgical treatment for gastric cancer in 54 patients over 80 years of age presenting from 1967 to 1989. The mean observation interval of the postoperative period was 24 days. In most cases, preoperative examinations revealed pulmonary, renal or cardiac disturbances. The postoperative morbidity rate was 40.7%, most commonly as a result of pulmonary complications. In the 2 patients with multiple organ disturbances, 1 died 1 day after operation following myocardial infarction and the other died of pneumonia 12 days postoperatively. Intensive care treatments were needed in the early postoperative period. The increased morbidity rate proved to be related to wide resectional procedures such as total gastrectomy, operative time in excess of 3 hours, and intraoperative blood loss greater than 300 ml (p less than 0.05). When adjustment for confounding variables was made in the multivariate discriminant analysis, the type of surgery proved to be a major independent risk factor related to postoperative complications. The majority of tumors (92.6%) could be removed by standard resectional procedures and curative operation was feasible for 36 (66.7%) patients. There were 24 deaths due to progression of the cancer. The crude overall 5-year actuarial survival rate was 23.8%, while the rate was 36.9% when correction was made for sex and age. The probability of long-term survival for patients in a relatively early stage of disease (T1-2, N0-1) was statistically better than for those with a more advanced disease (T3-4, N2, M1). Thus, even for patients in the 8th decade of life, gastric surgery can be considered, for carefully selected patients.
我们在此报告1967年至1989年间54例80岁以上胃癌患者的手术治疗结果。术后平均观察期为24天。在大多数情况下,术前检查发现有肺部、肾脏或心脏功能障碍。术后发病率为40.7%,最常见的原因是肺部并发症。在2例有多器官功能障碍的患者中,1例术后1天因心肌梗死死亡,另1例术后12天死于肺炎。术后早期需要重症监护治疗。发病率增加被证明与广泛的切除手术有关,如全胃切除术、手术时间超过3小时以及术中失血超过300毫升(p<0.05)。在多变量判别分析中对混杂变量进行调整后,手术类型被证明是与术后并发症相关的主要独立危险因素。大多数肿瘤(92.6%)可以通过标准切除手术切除,36例(66.7%)患者可行根治性手术。有24例因癌症进展死亡。粗略的总体5年精算生存率为23.8%,在对性别和年龄进行校正后,该率为36.9%。疾病处于相对早期(T1-2,N0-1)的患者长期生存的概率在统计学上优于疾病进展期(T3-4,N2,M1)的患者。因此,即使对于80多岁的患者,对于经过精心挑选的患者,也可以考虑进行胃手术。