Shriners Hospitals for Children, Cincinnati Burns Hospital, Cincinnati, OH 45229, USA.
Burns. 2009 Nov;35(7):949-55. doi: 10.1016/j.burns.2009.02.016. Epub 2009 Jun 6.
Antibiotic usage is essential for infection control but hastens emergence of antibiotic resistant microbes. In particular, Acinetobacter baumannii is an important pathogen because of its heightened ability to acquire drug resistance. The need for novel antibacterial agents led us to evaluate the sensitivity of drug-resistant bacteria to the antimicrobial activity of human beta defensin 4 (HBD-4). Clinical isolates of A. baumannii (N=14), Pseudomonas aeruginosa (N=15), and Staphylococcus aureus (N=20), including 10 methicillin-resistant (MRSA) isolates, were examined. All bacterial strains were susceptible to HBD-4 antimicrobial activity, with no correlation between antibiotic resistance and HBD-4 sensitivity. The results demonstrate that antibiotic resistant microorganisms, including MRSA, can be inhibited by HBD-4, which may represent an effective therapeutic agent for infections involving drug-resistant microorganisms.
抗生素的使用对于感染控制至关重要，但也加速了抗生素耐药微生物的出现。特别是，鲍曼不动杆菌由于其高度获得耐药性的能力，成为一种重要的病原体。对新型抗菌药物的需求促使我们评估耐药菌对人β防御素 4（HBD-4）的抗菌活性的敏感性。检测了临床分离的鲍曼不动杆菌（N=14）、铜绿假单胞菌（N=15）和金黄色葡萄球菌（N=20），包括 10 株耐甲氧西林金黄色葡萄球菌（MRSA）分离株。所有细菌菌株均对 HBD-4 的抗菌活性敏感，抗生素耐药性与 HBD-4 敏感性之间无相关性。结果表明，包括 MRSA 在内的抗生素耐药微生物可被 HBD-4 抑制，这可能代表一种有效的治疗药物，可用于涉及耐药微生物的感染。
