Shorr Andrew F, Owens Robert C
Washington Hospital Center, Washington, DC 20010, USA.
Am J Health Syst Pharm. 2009 Jun 15;66(12 Suppl 4):S8-14. doi: 10.2146/090087b.
Differences in the definition, demographics, risk factors, etiology, and treatment for health care-associated pneumonia (HCAP) versus community-acquired pneumonia (CAP) are discussed.
Health care-associated infections (HCAI) represent a population of outpatients with exposure to health care institutions and procedures who develop nosocomial-like infections. HCAI are etiologically similar to nosocomial infections with gram-negative organisms, methicillin-resistant Staphylococcus aureus (MRSA), and multidrug-resistant (MDR) pathogens predominating. These patients are ambulatory, community residents who often present to hospital emergency departments as would patients with community-acquired infection. Although many differences between HCAI and community-acquired infections, as well as HCAP and CAP, remain to be elucidated, the emerging evidence has identified multiple and important differences. Because of etiologic differences between CAP and HCAP, treatment strategies necessarily differ. Mistaking HCAP for CAP may result in the use of inappropriate empirical therapy, which is an established source of treatment failure, morbidity, and mortality. Thus, it is essential for physicians to be capable of recognizing risk factors for HCAI and HCAP as well as competently select and implement appropriate treatment strategies.
The etiologic differences between HCAP and CAP require different treatment strategies. No clinical or demographic characteristics nor signs and symptoms distinguish HCAP from CAP. Rather, physicians must rely on a thorough and careful history of each patient as well as their own clinical judgment.
探讨医疗保健相关肺炎(HCAP)与社区获得性肺炎(CAP)在定义、人口统计学、危险因素、病因及治疗方面的差异。
医疗保健相关感染(HCAI)是指接触过医疗机构及医疗程序的门诊患者发生的类似医院感染的感染。HCAI在病因上与医院感染相似,以革兰阴性菌、耐甲氧西林金黄色葡萄球菌(MRSA)及多重耐药(MDR)病原体为主。这些患者为非住院的社区居民,常像社区获得性感染患者一样前往医院急诊科就诊。尽管HCAI与社区获得性感染以及HCAP与CAP之间仍有许多差异有待阐明,但新出现的证据已确定了多个重要差异。由于CAP和HCAP在病因上存在差异,治疗策略必然不同。将HCAP误诊为CAP可能导致使用不恰当的经验性治疗,这是治疗失败、发病及死亡的既定原因。因此,医生必须能够识别HCAI和HCAP的危险因素,并能熟练选择和实施恰当的治疗策略。
HCAP和CAP在病因上的差异需要不同的治疗策略。没有临床或人口统计学特征以及体征和症状能够区分HCAP和CAP。相反,医生必须依靠对每位患者进行全面细致的病史询问以及自身的临床判断。