Abdel-Fattah K I, Bobek S, Sechman A
Department of Animal Physiology, Academy of Agriculture, Kraków, Poland.
Zentralbl Veterinarmed A. 1991 Jul;38(6):401-8. doi: 10.1111/j.1439-0442.1991.tb01028.x.
Food deprivation for 27 and 75h in cocks decreased serum levels of T3 maximally by 61.1% and increased the level of rT3 by 51.4% and that of T4 by 22.4%. Injection of a single dose of TRH (10 micrograms/kg b.w.) increased serum levels of all 3 iodothyronines in both fed and food-deprived animals. In fasted, TRH-treated birds the peak of serum rT3 was 80.5 and 73.3% above control levels in 27- and 75-hr food-deprived cocks, respectively (fed birds: 14.6 and 9.7%); the relevant data for T3 were: 78.3 and 40.4% (fed birds: 95.7 and 127.5%); for T4: 30.0 and 27.0% (fed birds: 9.2 and 6.1%). The greater relative increment of serum rT3 than T3 in food-deprived and TRH-treated cocks was supported by a fall of the serum T3/rT3 ratio to 78.7 and 27.9% in fed cocks and 27- and 75-hr fasted animals, respectively. We conclude, that food deprivation modifies the response of the hypophysis-thyroid axis to exogenous TRH in the sense that during fasting the production of rT3 is enhanced relative to T3.
公鸡禁食27小时和75小时后，血清T3水平最大降幅为61.1%，反T3（rT3）水平升高51.4%，T4水平升高22.4%。注射单剂量促甲状腺激素释放激素（TRH，10微克/千克体重）可使进食和禁食动物的血清3种碘甲状腺原氨酸水平均升高。在禁食且经TRH处理的鸡中，血清rT3峰值在禁食27小时和75小时的公鸡中分别比对照水平高80.5%和73.3%（进食鸡分别为14.6%和9.7%）；T3的相关数据为：78.3%和40.4%（进食鸡分别为95.7%和127.5%）；T4的相关数据为：30.0%和27.0%（进食鸡分别为9.2%和6.1%）。禁食且经TRH处理的公鸡血清中rT3相对T3的增幅更大，这一现象表现为血清T3/rT3比值在进食公鸡、禁食27小时和75小时的动物中分别降至78.7%、27.9%。我们得出结论，禁食改变了垂体-甲状腺轴对外源性TRH的反应，即在禁食期间，相对于T3，rT3的产生增强。
